Selank: Rapid response to stress and modulation of emotion

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Introduction

Selank development was directed by Myasoedov N.F., academician of the Russian Academy of Sciences (Institute for Molecular Genetics of the Russian Academy of Sciences), and Ashmarin I.P., academician of the Russian Academy of Medical Sciences (Lomonosov Moscow State University).


Myasoedov Nikolai Fyodorovich
born October 31, 1936

  • 1972 – Head of Biological Department of the Atomic Energy Institute
  • 1978 – present Vice Director of the Institute for Molecular Genetics of the Russian Academy of Sciences

Over 360 scientific papers and 2 monographs, over 150 inventor’s certificates and utility patents (USSR and Russian Federation), 4 international patents (USA, UK, France and Sweden).


According to Decree no. 87 of the President of the Russian Federation dated January 25, 2008, Myasoedov N.F., academician of the Russian Academy of Sciences, has been awarded the Order of Honour.


Ashmarin Igor’ Petrovich
September 20, 1925 – June 23, 2007

He was a distinguished Soviet and Russian scientist in areas of biochemistry and physiology.

  • 1964-1976 Head of Department of Biochemistry at the Leningrad State University
  • 1975-1986 Deputy Head of the Directorate of USSR Ministry of Defense
  • 1986-2006 Head of Department of Human and Animal Physiology at the Lomonosov Moscow State University

Author of the first Russian manuals including Molecular Biology (1974, 1977), Neurochemistry (1996), The biochemistry of the brain (1999); over 400 scientific papers and monographs.

Head of development and research of the world’s first synthetic neuropeptide (i.e., Semax). In 2001 I.P. Asmarin and a team of authors were awarded Russian Federation Government Award for development, manufacturing process management and introduction of the drug into clinical practice.

Ashmarin’s papers have been also awarded USSR State Award, Lomonosov Award (I Class), Orders of Lenin, October Revolution and Honour, as well as multiple medals.

Selank is manufactured by ZAO INPC Peptogen.
Address: Russian Federation, Moscow, 2 pl. Akademika Kurchatova St.

What is Selank?

Improves nervous system activity, recovers balance in cerebral emotional areas facilitating getting through stress, anxiety and depression.

Does not treat symptoms alone eliminating biochemical causes instead.

Activates processes appropriate in healthy body, ”adjusts” activity of nervous cells twisted by stress and pace of life, as well as enhances adaptation to unfavorable exposure.


Efficient protection

  • Induces only regulatory processes essential for an individual brain in each particular case
  • Provides natural regulation of CNS activity through peptide cascade mechanism.
  • Brain consumes only required amount of the drug. The remaining portion is split to absolutely safe natural amino acids.


Smart and advanced

  • Combines potency, complex action and safety
  • Intranasal administration followed by direct delivery to brain tissues
  • Original drug (not a generic one)


Studied and accepted

  • Action of the drug is confirmed by multiple scientific and clinical studies


Developed at the Moscow State University and the Institute for Molecular Genetics

  • Formula and principle of action were developed under direction of Ashmarin I.P. (distinguished Soviet and Russian scientist, academician of the Russian Academy of Medical Sciences);
  • The molecule was synthesized under direction of Myasoedov N.F. (scientist working in the fields of biochemistry and biotechnology, academician of the Russian Academy of Sciences)


Common use

  • Generally used in clinical practice since 1994
  • Commercially available in most Russian pharmacies
  • Used by leading Russian state clinics, the Ministry of the Russian Federation for Civil Defense, Emergency Management and Natural Disasters Response and the Russian Ministry of Defense

Why nasal drops were chosen as a dosage form?

Intranasal administration is the most effective administration route for drugs improving brain activity.

Therefore, nasal instillation along the olfactory nerves induces direct delivery to brain tissue. What are these drugs? They include polypeptides (i.e., compounds consisting of several amino acids).

Since Selank is a polypeptide, it is delivered to brain through olfactory nerves in just a few minutes. This fact determines rapid therapeutic effect.

  • Selank stands for rapid simple treatment and high potency.

Intranasal administration provides great advantages of Selank over injectable drugs/tablets because potency of the latter is substantially restricted by body protective barriers (e.g., blood brain barrier which protects brain cells from aggressive compounds). Thus, human body considers drugs as ”aggressors”. That is why, most of them do not reach the brain and only small amount is delivered to it.

Also, it should be considered that intranasal administration is not associated with any inconveniences for a patient or special procedures performed by qualified personnel.

Even in several minutes after contact with mucosa Selank action begins to help brain cells. Selank provides fast recovery and getting on with usual activity which are critical factors for everyone.

Uses

Depressiveness

Recently “depression”, ”mild depression” and ”depressiveness” are commonly used terms. Depression is a severe psycho-emotional disorder. It is characterized by dysphoria/bad mood and negative self-rating, as well as pessimistic estimation of own standing in the real world, past and future along with lower inducement to activity.

Depressed person suffers from hard rankling emotions and experience (i.e., dysphoria, melancholy and despair).

Will activity and self-rating are sharply decreased. Additionally, a patient feels futility of existence. The hardest psychiatric issue is depression treatment aimed to drive a patient out of this state.

However, depression develops for a considerable time preceded by yearslong pre-existing disease (i.e., depressiveness). Moreover, depressiveness can be observed in all at all ages.

Dosage for Depressiveness


Administration duration – 10 days


Instill 3 drops in each nasal passage twice a day


Administration course – 2 bottles
1-2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

The first symptom of depressiveness

The first ultimate symptom of depressiveness is stable mood lowering. As far as it is known, human life is similar to ”zebra crossing” because occasionally beneficial life gives way to negativity periods.

Work issues, family troubles etc. result in sharp mood decrease. In autumn and winter climatic factor makes contribution to existing negativity. Also, gloomy weather causes mood lowering when the sky is clouded for weeks inhibiting direct sunlight.

An antidepressant to treat chronic or episodic depressiveness in young or senior patients must meet following requirements: potency, safety, good tolerance associated with long-term administration, minimal drug interaction, rapid action onset, possibility of fast withdrawal without ”withdrawal syndrome”.

Selank (i.e., regulatory peptide) provides all these properties; so, it can drive a patient out of depressive state.

It promotes the fastest elimination of neurochemical disbalance in cerebral emotional centers which induces despondency, helplessness, dysphoria and worry. Thus, it helps to get through depression and effectively deal with concomitant symptoms.

Selank administration provides:

  • lower depressiveness, anxiety and internal stress
  • optimized activity of cerebral emotional centers
  • increased interest in life
  • better memory and mental alertness
  • improved tolerability of stressful situations (especially, change of perspective or team)
  • stimulated working capacity (including subtle one)
  • improved sleep
  • recovered activity of vegetative centers promoting prevention of depression.

Selank therapy: depression and depressive disorders

Selank is a drug of choice for therapy of community-minded patients looking toward maintenance of usual lifestyle and full working capacity along with minimization of negative sequelae of experienced stress and elimination of concomitant depressive disorders.

The drug promotes serotonin synthesis only because of its low concentration; in particular, low concentration of serotonin leads to depression development.

Stressority

It is not infrequent that one hears people say, ”Our life is full of stress”.
In terms of science, stress is a body response to significant environmental exposure (including social environment).

In this light, stress is a normal part of human life. It can be both positive (e.g., marriage, delivery of a child etc.) and negative one (work/family issues, illness of a closed one etc.).

Stressful situation alone is not a health hazard as compared with superstrong/long-term, frequent and chronic exposure of stress factors.

Unfortunately, possibility of complete elimination of stress-inducing factors is far from always. When normal rest is impossible, we often use alcoholic drinks, coffee or sedative tablets to solve this problem. Due to short-term effect, these agents do not facilitate rapid fatigue mitigation and getting through stress only worsening its sequelae instead. At the moment Russian scientists propose advanced drugs to combat stress.

Dosage for Stressority


Administration duration – 10 days


Instill 3 drops in each nasal passage twice a day


Administration course – 2 bottles
1-2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

Selank was specially designed for healthy individuals dealing with stressful/emergency situations.

It’s a regulatory peptide produced by human body as a response to stress. In case of insufficient endogenic production, additional amount of the peptide is required. Selank re-induces human regenerative reactions reduced or stopped by stress. Therefore, human body starts to treat itself. Thus, the drug provides natural getting through stress and nervous system sedation. This fact determines high potency and fast effect onset.

Even 1- or 3-day treatment course can improve patient’s status; full recovery can be achieved through stress mitigation at home in 14 days.

Improved mental capacity, stimulated memorizing/thinking processes and increased attention are additional advantages of Selank (i.e., antistress drug).

Ameliorated emotional and personal parameters are the first effect associated with Selank administration.

Intellectual action of Selank in healthy individuals

As a human neuropeptide, Selank affects healthy body precisely to the extent that is required to support and/or to recover CNS normal functioning damaged by unfavorable exposure.

The more evident abnormalities are, the stronger selective Selank action is to improve patient’s status.

By contrast, the better and healthier human body is, the less evident Selank action is observed due to absence of objects to be recovered. That’s why, Selank can stop stress without potential overdose hazards.

By the way, both adults and children suffer from stress. Mechanisms of stress response development in children and adolescents are the same as in adults. In childhood stress may be caused by other factors but results are similar to older groups.

Anxiety

Anxiety is an essential part of our life. It’s a common transient response to stresses of routine life. It’s unpleasant emotional experience presented as discomfort associated with uncertain perspective.

Normal anxiety facilitates preparation to unpleasant or dangerous situation caused by external factors. Anxiety is a transient feeling in a healthy individual.

Its continuance depends on duration of traumatic event. Whereas anxiety is an emotional condition, vegetative functions are activated along with mood change. Namely, hypertension, altered pulse rate and skin colour, increased perspiration etc. are observed.

In some cases, anxiety may induce fear (i.e., anticipation of particular instantaneous hazard such as fear of exam or death from severe disease/hazardous mission.)

Dosage for Anxiety


Administration duration – 10 days


Instill 3 drops in each nasal passage twice a day


Administration course – 2 bottles
1-2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

In addition to common anxiety caused by specific reasons, several patients experience long-term groundless uncertain excitement, premonition of danger, internal stress or fearful anticipation which are not associated with real hazard.

In order to calm themselves, patients are forced to be constantly busy. They are particularly characterized by restlessness, fussiness, accelerated rhythm of speech, constant finger rubbing and nail/lip biting. Often these presentations are associated with motor anxiety and vegetative reactions. Abnormal anxiety underlying a whole range of ”anxiety disorders” develops in the same manner.

Complex course of these disorders is associated with strong rationale for choosing a drug which must meet following requirements:

potency, safety, good tolerance, minimal drug interaction, rapid action onset, possibility of withdrawal without ”withdrawal syndrome”, possible use for prevention of anxiety conditions.

Selank (i.e., peptide anti-anxiety drug (anxiolytic)) is potent to manage anxiety conditions.

It promotes the fastest elimination of imbalance in cerebral regulatory systems inducing worry, anxiety and fear. Thus, anxiety condition may be cured.

Selank promotes:

  • lower stress, fear, external and internal stress
  • decreased depressiveness level
  • optimized activity of cerebral emotional centers
  • ameliorated behaviour
  • better memory due to drug influence on all (!) the stages of memory trace formation (i.e., memorizing, processing/structuring and retrieval of information)
  • improved mental alertness
  • improved tolerability of stressful situations (especially, change of perspective or team)
  • stimulated working capacity (including subtle one)
  • improved sleep
  • recovered functioning of vegetative centers.

Selank is a drug of choice for therapy of community-minded patients looking toward maintenance of usual lifestyle and full working capacity along with minimization of negative sequelae of experienced stress and elimination of concomitant anxiety disorders.

Easy fatigability

Modern life necessitates rapid rhythm, great current of data to be assimilated and tight time to make critical decisions. All these factors promote increase in mental work intensity, longer working time and reduced qualitative rest duration.

Overfatigue symptoms (i.e., easy fatigability, general weakness and constant fatigue) are mentioned in 80% of active population in large megalopolises.

Working stress (”information neurosis”, ”manager syndrome”) caused by three factors (great current of important data to be assimilated, tight time and high motivation of activity) plays a key role in development of mental, psychic and emotional overexertion. It is the most common condition in those who deal with increased responsibility, competition and uncertain outcome of their own beginnings (i.e., in chronic emotional stress conditions).

Overexertion and overwork may cause abnormal conditions such as chronic fatigue syndrome, impaired mental capacity, depression, nervous breakdown and neurasthenia.

Dosage for Fatigue


Administration duration – 10 days


Instill 3 drops in each nasal passage twice a day


Administration course – 2 bottles
1-2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

Nervous overfatigue is characterized by easy fatigability, weakness and drowsiness associated with emotional tension (anxiety, irritability, emotional instability etc.), various visceral disorders (palpitation, cardiac pain, shortness of breath, dizziness, headache, digestive disorders etc.), as well as sleep disturbances (complex sleep onset, superficial nocturnal sleep, lack of vivacity after nocturnal sleep) which sharply decrease quality of night’s rest. As a result, hypomnesia, decreased attention, as well as lower mental and physical performance are observed.

Constant overexertion and overwork may cause abnormal condition called chronic fatigue syndrome.

Selank action to manage fatigue symptoms:

  • improvement of higher cerebral functions (including speech, thinking and motion coordination);
  • support and recovery of working capacity;
  • amelioration of memory and attention (especially, in overfatigue conditions);
  • psychic fatigue mitigation (e.g., mental fatigue associated with routine operator performance).

Selank will recover sleep/awakening cycle (if it was damaged) providing both faster sleep onset and easy waking up.

Selank is manufactured as nasal drops. This dosage form is associated with easy administration and the most rapid effect onset resulting from fast drug delivery to brain cells (2-4 min).

The drug is metabolized to natural amino acids without any undesirable side effects. Overdose have not been detected yet (even followed by substantially greater doses).

Of course, Selank cannot replace balanced diet or good rest which are so essential for human body. However, it will faithfully help brain cells to ”stay fit” and appropriately work even in stress and overfatigue conditions. Moreover, it will provide reliable preventive protection from damaging factors.

The most acceptable dosage is 2 drops instilled in each nasal passage for 3 times a day; administration course: 10-14 days.

Late last age national scientists developed an advanced drug which is known as Selank the neuropeptide. Due to high safety level, this natural regulator of CNS functions does not provide exhaustive action; withdrawal syndrome is absent. It promotes energy production in cerebral neurons, increases synthetic processes and improves connection between various brain cells and structures. Thus, energy deficiency underlying fatigue processes is eliminated, as well as memory capacity and mental alertness increase.

Anti-stress property is an important action of Selank. Selank administration is suitable for professionals needed continuous mental alertness. Also, it is indicated in case of increased mental load, severe stress, chronic fatigue prevention and to improve general working capacity and memory.

Neurasthenia

Selank promotes the fastest elimination of imbalance in cerebral regulatory systems inducing worry, anxiety, fear and irritative weakness. The drug administration results in:

  • lower anxiety, fear and internal stress
  • decreased depressiveness level
  • optimized activity of cerebral emotional centers
  • stimulated working capacity (including subtle one)
  • improved mental alertness
  • improved tolerability of stressful situations (especially, change of perspective or team)
  • improved sleep
  • better memory due to drug influence on all the stages of memory trace formation (i.e., memorizing, processing/structuring and retrieval of information)
  • normalized functioning of vegetative centers.

Dosage for Neurasthenia


Administration duration – 14 days


Instill 3 drops in each nasal passage twice a day


Administration course – 3 bottles
1-2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

Neurasthenia: therapeutic regimen (Selank 0.15%)

All these facts combined determine plasticity of Selank pharmacological and therapeutic effects.

The drug provides significant anxiolytic effect in patients with high level of anxiety disorders.

Stimulating antiasthenic action is more evident in patients with increased mental exhaustability and physical weakness. Therefore, Selank is the first ”smart” drug.

Neurasthenia (i.e., asthenic neurosis) is a disease characterized by increased non-controlled irritability, easy fatigability, anxiety, mood swing, general weakness, dizziness, limb tremor and bad sleep.

Actually, neurotic disorders include conditions mainly resulting from working stress (”information neurosis”, ”manager syndrome”) caused by three factors: great current of data to be assimilated, tight time and high motivation of activity.

They are common in managers whose activity is associated with increased responsibility, competition and uncertain outcome of their own beginnings. Also, mental and physical overfatigue, chronic sleep deprivation and emotional overload are pathogenic factors.

In addition, asthenic constitution, malnutrition, avitaminosis, severe somatic diseases and intoxication promote appearance of neurasthenia symptoms.

Asthenia is the main symptom of neurasthenia. It is presented by increased mental and physical fatigability, absence of mind, overexhaustion, decreased working capacity, required long-term rest which does not, however, result in complete restitution.

Increased mental exhaustability is combined with excessive excitability (i.e., irritable weakness phenomena).

Also, typical neurasthenic symptoms include tension headache, sleep disturbances, multiple somati vegetative disorders (including sweats, impaired cardiovascular, gastrointestinal, respiratory and sexual functions etc.).

Generalised anxiety disorder

Selank promotes the fastest elimination of imbalance in cerebral regulatory systems inducing worry, anxiety and fear. In particular, the drug administration results in:

  • lower anxiety, fear and internal stress
  • decreased depressiveness level
  • optimized activity of cerebral emotional centers
  • ameliorated behaviour
  • better memory due to drug influence on all the stages of memory trace formation (i.e., memorizing, processing/structuring and retrieval of information)
  • improved mental alertness
  • improved tolerability of stressful situations (especially, change of perspective or team)
  • stimulated working capacity (including subtle one)
  • improved sleep
  • recovered functioning of vegetative centers.

Selank is a drug of choice for therapy of community-minded patients looking toward maintenance of usual lifestyle and full working capacity along with minimization of negative sequelae of experienced stress and elimination of concomitant anxiety and psycho-vegetative disorders.

Dosage for General anxiety disorder


Administration duration – 14 days


Instill 3 drops in each nasal passage 3 times a day


Administration course – 4 bottles
2 administration courses per year

  • each bottle contains 60 drops
  • instill on nasal mucosa only

Selank therapy: anxiety disorders

Anxiety disorder is a common borderline psychoneurological abnormality. These disorders are especially common in working-age patients leading to impaired adaptation in usual life and significant economic losses.

Adaptive disorder associated with anxious mood and generalised anxiety disorder are the most common anxiety disorders.

Adaptive disorder is associated with excessive anxiety or other emotional reactions in the setting of complicated adaptation to individual stressful situation (e.g., sleep disturbances, altered appetite, non-specific cardiovascular/gastrointestinal complaints, decreased mental alertness, irritability, increased exhaustability and fatigue).

Generalised anxiety disorder is characterized by frequent or continuous apprehension and anxiety caused by real events/circumstances resulting in evidently increased patient’s concern (unjustified hyperbolic apprehension).

These disorders are associated with global anxiety developing regardless of particular event. Continuous excessive anxiety is targeted at multiple life circumstances. Worry, tension and fear may be complicated by physical distresses such as nervous stomach, shortness of breath and palpitation. Anxiety disorders are commonly associated with depressive disturbances.

In spite of stable anxiety (i.e., primary symptom unifying all the anxiety disorders), following presentations are mentioned:

fearfulness, impatience, fussiness, constant tension sensation, lack of relaxation, impaired mental alertness, lower mental capacity and memory, sleep disturbances.

Anxiety disorders are accompanied by high incidence of cardiovascular, gastrointestinal and allergic diseases, musculoskeletal, metabolic and renal illnesses, respiratory disorders, as well as migraine.

Increased anxiety causes 1.9 and 4.5 higher risks of fatal myocardial infarction and sudden death, respectively.

Safety

Studies and application practice of Selank showed absence of following effects:

  • Hypnosedative and myorelaxative action
  • Allergizing and local irritative action
  • Toxic, genotoxic and embryotoxic actions
  • Teratogenic and mutagenic actions
  • Hormonal activity
  • Exhaustive effect on CNS
  • Negative effect on functions of cardiovascular, respiratory and other critical body systems
  • Interaction with other drug groups (in case of co-administration)
  • Drug addiction and habituation
  • Withdrawal syndrome.

Overdose

The drug is low-toxic due to metabolization to natural amino acids. Therefore, even significantly increased single dose have not induce overdose symptoms yet.

Pregnancy and lactation

Administration is not recommended due to lack of clinical trials in this period.

Contraindications

Hypersensitivity to drug ingredients is the main contraindication.

Pharmacodynamics

As a human neuropeptide, Semax affects human body as an ”endogenic expert”. Namely, it works precisely to the extent and in the direction that is required to support and/or to recover normal functioning of individual CNS debilitated or damaged by exposure of unfavourable factors.

The more evident abnormalities are, the stronger ”expert” action of Semax is observed. Contrariwise, the better and healthier CNS is, the less evident Semax action is observed due absence of objects to be recovered.

Primary pharmacological effects

Type of action Mechanism of action Characteristic
Anxiolytic

(anti-anxiety)

The drug influences on primary element of anxiety disorder formation through prevention of increased noradrenaline and serotonin levels along with decreased enkephalin concentration in cerebral emotional areas. Moreover, increased functional significance of inhibitory GABA system (i.e., mechanism of action specific for absolute majority of tranquillizers) is just a secondary response to already existing mediator imbalance. Potency is comparable with corresponding property of benzodiazepine drugs
Antidepressive Mechanism of this action intimately connected with its anxiolytic effect is determined by recovery of enkephalin and serotonin levels in emotional areas. Selank promotes serotonin synthesis only in case of low concentration resulting in depression. Due to high monoamine level causing anxiety development, serotonin synthesis is inhibited. Although this effect rises therapeutic possibilities of the drug, it does not have individual clinical relevance
Psychostimulating Enhancement of dopamine synthesis in cortex and interbrain This effect results in asthenic condition reduction; ”non-exhausting” action sets the drug apart from conventional psychostimulants
Neurometabolic This effect is determined by antihypoxic activity Beneficial effect on mnestic and cognitive cerebral functions is defined in healthy and sick individuals. Selank activates processes of learning, memorizing (recording, consolidation), analysis and retrieval of information, as well as improves attention parameters both in normal brain and in the setting of organic brain dysfunctions.
Neuroprotective Increased neurotrophin synthesis in brain tissue (BDNF is a cerebral neurotrophic factor)
Nootropic Better memory trace formation
Vegetotropic Recovered higher vegetative center functioning Improved vegetative provision of human body activity in emotional tension conditions
Cardioprotective Increased leu- and met-enkephalin blood levels Prevention of intracardiac hyperactivation of sympathetic nervous system
Stress-protective This effect is characterized by psychotropic and vegetotropic actions It eliminates emotional negative tension associated with stress, recovers appropriate motivating activity, activates adaptive behaviour aimed to achievement of beneficial outcome and manages stress-induced somatic disorders

Plasticity of Selank pharmacological and therapeutic effects is resulted from normalizing influence on activity of main brain neurotransmitter systems. The drug provides significant anxiolytic effect in patients with generalised anxiety disorder. At the same time, stimulating antiasthenic action is more evident in individuals with neurasthenia. Therefore, Selank is the first ”smart” drug.

According to studies, it was proved that polypotency and variety of the drug effects (e.g., influence on activity of serotoninergic, catecholaminergic and opiatergic systems etc.) are mainly accounted for activation of biochemical cascade processes in brain cells prolonging and enhancing curative effect of the drug.


Spectrum of drug action in patients with generalised anxiety disorder (orange area) and neurasthenia (green area).

Pharmacokinetics

Affected by various proteases, peptide drugs undergo rapid biotransformation in human body. Obtained peptide fragments have their own activity. They can make substantial contribution to pharmacological action of basic drug or even change it. That’s why, studies of pharmacokinetics and mechanism of action of peptide drugs are overwhelmingly important.

Pharmacokinetics and primary directions of Semax biotransformation which are responsible for high potency and multifunctionality were evaluated by means of multiple studies performed by scientists hosted by the Institute for Molecular Genetics of the Russian Academy of Sciences and Faculty of Biology of the Lomonosov Moscow State University.

It was found that intranasal route is the best for Selank administration enabling:

  • rapid penetration through blood brain barrier (so, lower doses may be administered);
  • high bioavailability (92.8% of active ingredient)
  • fast clinical effect (the drug is detected in plasma and brain tissues in 30 sec and 2 min after administration, respectively)
  • concentration in archeocortex and interbrain (i.e., Selank targets)
  • long-term action (20-24 h).

Biotransformation and elimination:

  • Primary biodegradation to peptide fragments is influenced by dipeptidyl carboxypeptidases. Tri- and dipeptides (Thr-Lys-Pro, Arg-Pro and Gly-Pro) mainly providing drug effects are primary products of this process.
  • Further degradation is continued to individual amino acids whose outcome is similar to natural ones.

According to studies, it was proved that polypotency and variety of the drug effects (e.g., influence on activity of serotoninergic, catecholaminergic and opiatergic systems etc.) are mainly accounted for activation of biochemical cascade processes in brain cells prolonging and enhancing curative effect of the drug.

Intranasal administration has following advantages:

  • penetration into brain along sensory nerves
  • absence of presystemic metabolism in liver
  • no drug interaction with other drugs (intranasal agents with local vasopressoric action should not be co-administered with Selank)
  • easy painless use.

FAQ

As a matter of interest, why were nasal drops chosen as a dosage form of Selank?

This dosage form enables rapid delivery of the drug to cerebral nerve tissue. Selank absorbs into blood from nasal mucosa; then both olfactory nerves directly connecting nasal mucosa with brain, and bloodflow deliver it to brain nerve cells. As a result, the peak amount reaches the brain without degradation in stomach or liver.

I use antidepressants and I’m dissatisfied with their inhibitory action. May I administer Selank instead?

Selank has full-scale antidepressive action to manage so-called exogenic depressions associated with emotional experience, unfavourable living conditions etc.). The drug does not induce drug addiction, habituation and inhibition. Alternately, it decreases fatigability, increases working capacity and provides anti-anxiety activity.

Is Selank suitable for administration in critical stressful situation?

It’s one of primary indications of this drug in healthy individuals. Selank rises stress tolerability and recovers normal behavioural reactions (i.e., faster solution of stressful situation). Beneficial effect on memory, short-term administration course and evident effect since the first administration are additional advantages of the drug.

How soon is effect observed after administration of Selank 0.15%?

It depends on administration purpose and patient’s disease. Drug effect in healthy individuals (those who suffer from jitteriness, worry, easy fatigability, emotional stress etc.) is observed in 5-20 minutes after administration. Drug effect in patients with anxiety conditions is observed within the first day (disease duration: 1 month – 1 year) and since the 3d day of use (if the disease lasts for years).

As a matter of clarification, is Selank administration allowed in persons driving a car?

Yes, it is allowed. The drug does not provide hypnotic action. Moreover, it increases attention and mitigates fatigue, excitement and anxiety. That’s why, it can be administered by a wide variety of professionals who required increased mental alertness and special motion coordination (e.g., drivers, plant operators).

What diseases may be considered as contraindications for Selank administration?

Selank is a safe drug which does not provide harmful impact on human organs and tissues. Therefore, it can be used in the setting of almost all concomitant diseases. The drug does not interact with other medications. Also, it does not influence on effects of other drugs.

Is Selank allowed to be co-administered with antidepressants?

Yes, it is allowed. The co-administration will result in higher potency of antidepressants. Due to own antidepressive action, Selank may be used instead of conventional antidepressants to treat depression which is not associated with mental diseases.

Is Selank compatible with alcoholic drinks?

Yes, combined use is possible because the drug does not interact with this type of drinks. Selank reduces ethanol toxicity and its unfavourable action on brain functions.

At the moment of purchase a pharmacist warned me against Selank storage in a refrigerator. My job involves much travel, so I intended to carry it in my handbag during use. What should I do?

Actually, you can carry Selank drops with you; take an unsealed bottle away in a several-day trip with no risk of spoiling.

Store it in a refrigerator if you are going to use Selank not immediately but after a long time.

May I use remaining half-bottle, for example, in 1-2 months? How long can I store an unsealed Selank bottle to maintain drug potency?

An unsealed Selank bottle can be stored within 6 months if storage conditions are met. Namely, store it closed in a refrigerator. Thus, the drug will maintain all beneficial properties; in this case, it can be used in 2 months or later. Selank contains an eco-friendly preservative to avoid drug contamination with microorganisms which may reduce its potency.

Product photos

Where to buy?

http://rupharma.com/selank (shipping from Russia at lower price)
http://mospharma.com/selank (shipping from EU at higher price)

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