Well toned body – this is not only beautiful, it is a matter of health. Excess body fat is reflected on the normal operation of heart and puts excess pressure on joints. Metformin may even assist in those cases where diets do not work.
What is Metformin?
Metformin is a compound that helps to lower blood glucose levels and is usually used to treat type 2 diabetes. It is especially effective for people who are overweight and obese, because it helps to lose weight even in cases where the diet is not effective. If you adhere to the treatment regimen, it practically does not cause side effects. Metformin is an approved medicine by the WHO for diabetics.
The compound was first discovered in 1922. When treating diabetes, an additional positive property was noticed: the patients’ weight became stable and gradually decreased. Because of this, it began to be used to lose weight in healthy people. Doctors also prescribe Metformin for the treatment of polycystic ovary. It is being tested as a remedy for oncology, to slow down the aging of the body.
Different types and dosages of Metformin. Which is better?
Metformin is available in tablet form by many pharmaceutical companies. Packaging comes in 30 to 120 tablets. Each tablet contains 500 mg, 850 mg or 1000 mg of active substance. The choice of a particular brand depends on the dosage and they do not differ in the mechanism of action. If you need to take 2000 mg per day, then it is better to buy tablets of 1000 mg of substance in each tablet. The substance is manufactured under various trade names. The most popular ones being:
- Avandamet (500 and 1000 mg), available in Spain GlaxoWellcome.
- Glucophage, considered the very first drug in this group, is produced by Merck Sante in France, three options are available (500, 850, 1000 mg).
- Metfogamma is also produced in various concentrations at the Dragenofarm Apothecary Puschl plant in Germany.
- Siofor is another popular medicine with different dosages, manufactured by Berlin Chemie in Germany.
Other manufacturers throughout the world TEVA, Sanofi, Richter, Astrafarm, Sandoz, Novartis, Indar, Zentiva and Hexal.
There are also combined drugs, for example Reduxin, which includes both sibutramine and metformin, two powerful components to reduce body weight.
Metformin Indication For Use
Metformin is usually prescribed by doctors to treat type 2 diabetes in overweight patients. The medicine is used for adults and children from 10 years old. Often it is combined with insulin. The drug is recommended to reduce the risk of pathologies of the cardiovascular system with excess weight. This is the so-called first-line remedy for cases when physical activity and diet do not lead to weight loss.
In a study whose results were published in 2012, it was shown that the substance reduces body weight in individuals without diabetes, but with obesity and hypertension. The effectiveness of the drug to eliminate excess weight in children was also confirmed.
Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans. In spite of its widespread use, the mechanisms by which metformin exerts favorable effects on aging remain largely unknown. Further, not all individuals prescribed metformin derive the same benefit and some develop side effects.
The Body’s Reaction to Metformin
In the human body glucose is the main energy unit. Moreover, non-carbohydrate compounds are also converted into it. This process is called glucogenesis. With diabetes, its speed increases by 3 times, the food very quickly turns into glucose, so its concentration in the blood is significant.
How does Metformin for weight loss work? It’s able to slow down this process by about 30%. In addition, it activates the production of certain enzymes, which ar responsible for the energy balance, the exchange of glucose and fats in the body.
With an excess of sugars in food, cells do not recognize insulin, they lose their sensitivity to it. This causes its increased production. The hormone, in turn, gives the body a command to store calories, their excess turns into fat reserves. Metformin normalizes tissue susceptibility to insulin. If there is no excess hormone, fat storage does not occur.
How Does Metformin Help With Fat Loss?
The medicine has a wide range of effects on the body, which ultimately causes a decrease in body weight:
- Lowers blood sugar levels.
- Slows down the rate of synthesis of glucose from various compounds.
- Reduces the production of monosaccharide in the liver due to inhibition of glucogenesis.
- Increases insulin sensitivity.
- Limits intestinal absorption of glucose.
- Normalizes fat metabolism.
- Lowers cholesterol and triglycerides.
- In some people suppresses appetite.
If you limit the intake of carbohydrates, then as a source of energy, the body will begin to expend fat reserves.
How To Take Metformin
Pills are a medicine. Before you start taking them, you should carefully read the instructions for use for weight loss metformin, follow it, do not exceed the recommended dosage.
Metformin Admission Regimen
In the first week, 500 mg of Metformin should be consumed once a day, best after dinner. This should not be done at night or on an empty stomach.
In the second week, the dosage of the drug can be increased by another 500 mg, take 1 tablet twice a day. Then you should gradually increase the amount to be taken up to 1500-2000 mg.
The maximum allowed daily dose is 3000 mg, divided into equal parts of 1000 mg each. But such high concentrations require constant monitoring and control of a physician and should be prescribed only after the extension of the necessary examination and blood test. For people without diabetes, striving only for weight loss, do not exceed 1500 mg per day.
How To Take Metformin For Weight Loss
Tablets must be taken 1 or 2 times a day after meals or with meals. This approach slows down the absorption of the compound and reduces the appearance of unpleasant consequences. If it is difficult to swallow the whole tablet, it is allowed to divide it in half and take the particles one after another.
What To Observe While Taking Metformin
During the Metformin therapy, it is strictly forbidden to drink alcohol to avoid dangerous complications. Caution should be combined with anticoagulants. Concomitant use with antibiotics, non-steroidal anti-inflammatory drugs is not recommended. They are often found in joint preparations, such as Teraflex Advance. So you need to be careful. It is better to drink tablets with a difference of 2 hours. If you simultaneously use thyroid hormones or hormonal contraceptives, then the effectiveness of metformin is reduced.
As for the restrictions on food, you will have to give up sugar and reduce the amount of carbohydrates in the diet. If you do take sugar, you may experience issues with the gastrointestinal tract and weight will not decrease.
Metformin diet also involves the rejection of grapes and bananas, requires a strong restriction in potatoes, pasta and pastries. Do not eat oatmeal and white rice. It is worth giving preference to protein foods such as meat, fish, milk and vegetables.
Duration Metformin Intake
For diabetes, the course of administration is determined by the doctor. To reduce weight, you need to take Metformin for no longer than 21 days. After that, take a break for 2 months, then the course can be repeated. This is to prevent addiction.
What Kind Of Results Can You Expect When Taking Metformin?
You will not lose weight quickly by taking only tablets, however on average you can expect to loose 3 kg per course of administration. To make the drug work more effectively you should adhere to a low-carb diet. In which case for two cycles of therapy and a low-carb diet between them, you can lose around 10-12 kg.
For active fat burning, athletes use Clenbuterol simultaneously with Metformin. But this approach is applicable only to bodybuilders with a special diet.
Contraindications And Side Effects of Metformin
Taking the drug has many contraindications. Therefore, it is best to consult your physician before starting a course of treatment.
Metformin is contraindicated in the following cases:
- Kidney disease.
- Persons with serious lung and liver disease.
- During a low-calorie diet (less than 1000 kcal per day).
- During pregnancy and lactation.
- Myocardial infarction.
- Persons over 60 years old and children under 10 years old.
- During hard physical work or hard training.
It can not be used before radiography with contrast (the introduction of iodine preparations) and after it for 2 days, so as not to increase the burden on the kidneys.
Side effects may include a metallic taste in the mouth and loss of taste, loss of appetite, nausea, and diarrhea. In rare cases, a rash appears on the skin. To avoid them, you should start taking the minimum dose, gradually increasing it.
With prolonged use, vitamin B12 vitamin deficiency occurs, a decrease in thyroid stimulating hormone with hypothyroidism, and a decrease in testosterone levels in men. When using high doses, impaired renal function.
Feedback On The Use Of Metformin
Metformin is an affordable and effective weight loss drug that is well tolerated by most people. Here are some real reviews from those who have tried this medicine themselves.
I wanted to lose 2-3 kg. After taking Metformin, diarrhea developed for several hours. In the evening, I realized that my morning diet full of fast carbohydrates was to blame. Redefined my approach to nutrition and took Metformin for two weeks. My result: minus 1.5 kg.
After an unsuccessful pregnancy I gained 15 kg. After reading reviews about Metformin and studying the instructions, I decided to take it. I have no problems with sugar and insulin. My results: -4 kg in 10 days of admission and lack of appetite and cravings for sweets. From side effects: liquid stool in the early days of taking the drug and becoming tired more easily because of a low-carb diet.
My weight stood at one level and would not move. After blood test, it turned out that I had high insulin when the glucose was absolutely normal. This did not allow my body to part with extra kilograms. I started to take 1000 mg Metformin. One tablet in the morning and one in the evening. Weight gradually decreased, which made me happy.