Khavinson’s Bioregulatory Peptides: How to Advance Immortality


According to Friedrich Engels, life is the mode of protein bodies existence. Unfortunately, even Engels knew that nothing lasts forever, and a human body is destined for gradual degradation and destruction; finally, it will be at peace returning onto the ground. Actually, both scientists and amateurs search for all kinds of ways to prolong life (especially, its healthier part). However, body resistance to diseases is an essential factor of longevity. Bioregulatory peptides invented by Professor Khavinson became one of approaches that can be literally a panacea.

What are peptides?

Nowadays the sheer term ”peptides” raises eyebrows of a miscognizant person. This is about the same reaction of a non-sportsman to the ”protein” term. It took plenty of time to make most people know that protein means just pure proteic substance as distinguished from ”muscle pharm products” which transform a bodybuilder into a ”superman” in leaps and bounds. The above is also true of nootropics (i.e., drugs designed to improve ”comprehension”). Now it’s time for peptides.

Our body represents a ”skyscraper” made of protein structures. A cell is the smallest structural unit of our body, organs and tissues. It is alive as long as cell division lasts. Nevertheless, the number of divisions is genetically determined. A cell of any organ/tissue can divide for 50 times during a human life. Since the fact was established by an American scientist Leonard Hayflick, the limit has the same name (i.e., the Hayflick limit). Due to ageing and diseases, our organs and tissues deteriorate while number of cell divisions decreases. If it exhausts, apoptosis (i.e., cell death) will come.

Data on a determined number of cell divisions is stored in a genetic apparatus (i.e., DNA). This X-shaped structure is located in a cell nucleus. ”Shoulder” of DNA is termed as a ”telomere” that shortens physically when the number of cell divisions is exhausted. Then, we go right up to the edge of importance of a peptide representing a small protein with a certain sequence of amino acids which is specific for the given tissue. Penetrating into a human body by one way or another (e.g., by means of an injection or an oral capsule), the peptide passes freely through all the tissue barriers (i.e., cell and nuclear membranes) and integrates into DNA structure just at the site of shortened telomere as per the complementation principle.

The peptide ”elongates” a telomere by 42% (i.e., approximately halfway!). This recovers capacity of DNA for protein synthesis and, actually, prolongs life of a cell. We have already made it clear that longer cell division prolongs its life. In terms of a tissue (organ) which consists of these cells, this means restoration of its function and structure. In turn, in terms of entire body, this results in longer life and better quality of life, as well as prevention and treatment of age-related diseases.

But there is one catch. Peptide production is being developed rapidly at the moment. Well, safety and efficiency of a peptide depends not only on amino acid sequence and hormone clearance degree, but also on size of an amino acid chain (molecular weight). For example, let’s compare the substance of interest and a medical cerebroprotective polypeptide (i.e., Cerebrolysin). The weight of the latter is 10000 Da. At the same time, molecular weight of a bioregulatory cerebroprotective agent developed by Professor Khavinson is 400 Da. The value is a one milliardth of a meter (i.e., a nanometer). This represents an unmatched advantage of all the 40 peptides developed by the Institute of Bioregulation & Gerontology in Saint Petersburg. Since we need to have a line on activity of the Institute, Oksana Anatolevna Orlova (MD, PhD, a research officer of the Saint Petersburg Institute of Bioregulation & Gerontology and Ageing Bioregulation Laboratory; cosmetologist; anti-ageing medicine, injection and machine cosmetology expert) replied to our questions.

Certainly, we are interested in going for immortality.

Are bioregulatory peptides harmful or not?

It’s impossible to do any harm with peptides developed by Professor Khavinson. So, we will try to understand why. The fact is that the protective system (i.e., immunity) controls all the substances fed to a human body. Thus, it synthesizes antibodies to form a response to all of them. The information falls within our ”image library” like this. As for nanopeptides, antibodies are not produced. The immunity can’t control them because of too fast and unhindered uptake. If antibodies to a substance are absent, no allergic reactions, side and dose-dependent effects, as well as idiosyncrasy will be detected. So, the peak efficiency is not associated with any harm. The revolutionary breakthrough meets a concept of advanced alternative medicine. The international scientific community classifies the fact exactly this way.

The advanced therapy is especially of interest to manage premature ageing. For example, a 35-year-old person demonstrates 3-5 or more concomitant chronic diseases and a person above 65 years old has 5-8 at least. Thus, although a combined multi-drug therapy is required, it is ruled out because of insufficient safety of these agents. At the same time, a combined treatment with bioregulatory peptides is recommended. Let’s focus on the fact that peptides (i.e., strategic cumulative drugs) demonstrate their effect after a while when a stimulation dose has been accumulated and a ”response” to the therapy has been already created.

When were peptides discovered?

40 years ago, peptides were discovered during search for tools to increase personnel combat efficiency under radioactive exposure in the Kirov Military Medical Academy. It has been found that short chains of amino acids (2–3–4 АA) can conscribe cell division reserve and stimulate protein biosynthesis to repair structure and function of damaged organs and tissues. Since then an innumerable number of cultural, biological and clinical trials were carried out. They confirmed efficiency of short bioregulatory peptides. The discovery survived the test of time. The largest clinical trials were performed on separate occasions. They include rescue of Komsomolets submarine crew (45 persons) in 1989; research of Nadym performed through Gazprom (11,000 persons); study of group of the Saint Petersburg Institute of Bioregulation & Gerontology employees (50 persons) performed for 15 years; an annual preparation of the National Rhythmic Gymnastics Women’s Team to the 30th Olympic Games in London (2012).

How are peptides produced?

Peptides are produced by extraction of tissues of young calves (<12 months old) or laboratory biosynthesis. Therefore, these small constructive proteins exist for all the organs. Since all these substances are organ-specific, they repair only structure and function of the organ they were derived from. In particular, cerebral peptides restore brain and its functions. In turn, peptides extracted from liver, cartilages, vessels and thyroid repair tissues of liver, cartilages, vessels and thyroid, respectively. Thus, about 40 products were produced. A peptide of pineal gland (epiphysis) that represents a neuroimmunoendocrine ”general officer” of a human body is a ”gold standard” of longevity. Epiphysis coordinates functions of all the endocrine systems by means of its own hormone (i.e., melatonin which is also known as a ”youth hormone”). It is commonly known that hormones lead our vital status entirely. For example, melatonin blood and urine levels are associated with biological age of a human body. Therefore, epiphysis is a universal structure which restores all the organs and tissues. Moreover, it is a potent cancer protector.

What peptides are ready to improve our health? What is healing process like?

Nowadays, there are three dosage forms of peptides (i.e., transdermal (cosmetic products), oral (oral administration and general therapeutic effect) and injectables. Transdermal and oral dosage forms are available for broader audience. To facilitate distribution of these non-hazardous substances, they were termed as BAAs distributed through chain retailers. However, we should differentiate BAAs and peptides. BAAs can’t recover structure and function of tissues. In contrary, this is a primary purpose of peptides. Due to impact on a cause of a disease (i.e., organ destruction and their dysfunctions), peptides can be considered as etiotropic drugs. Havinson’s peptides can be found easily around the web.

Capsules are divided into two groups (i.e., cytomaxes representing natural tissue extracts and cytogenes biosynthesized in a laboratory). Despite comparable intensity and duration of the effect, some products are substantially cheaper than others. Oral peptides are dispensed by 60 capsules in a package (i.e., a monthly protracted treatment). To provide treatment and prevention, a capsule should be taken twice a day. Thus, an evident effect (e.g., an analgesic one) will be detected in 2 weeks at the soonest. In this case, a protracted treatment should be conducted for 2 times annually (i.e., in spring and autumn demonstrating seasonal flare-ups of any disease). In terms of treatment, 3-4 treatment courses should be conducted annually. To obtain a rapid therapeutic effect, a dosing rate should be increased to 2 capsules administered twice a day.

Epiphyseal peptide, structural sequence of amino acids: alanine – glutamine – asparagine – glycine (Ala-Glu-Asp-Gly).

It must be taken into account the fact that peptides should be used in combination because each person above 35 years old has at least 3-5 concomitant chronic diseases. So, a vascular peptide should be included in each therapeutic schedule. For example, improved blood circulation of an organ accelerates metabolism (M). Currently injectable peptides (i.e., extracts and biosynthesized products) are available for all the organs and tissues. However, only 5 of them were certified as medications 40 years ago. So, they are commercially available in pharmacies:

  • Cortexin is a cerebral peptide included in the National Register as a first-line drug to treat and to prevent infarction and stroke.
  • Thymalin is a peptide of thymus (i.e., central organ of immunogenesis).
  • Retinalamin is a retinal peptide.
  • Epithalon is an epiphyseal peptide.
  • Prostatilen is a prostatic peptide.

What does the future hold for bioregulatory peptides? How long does it take to develop a new drug?

All the peptides are rather intended for treatment and prevention. Even Nikolai Ivanovich Pirogov said that preventive medicine is the medicine of the future. Indeed, to prevent a disease is easier and cheaper than to treat it. You should start the use of peptides at 30 years old (i.e., the beginning of ageing and disease formation).

Sometimes even decades can elapse between invention and manufacturing application of a product. Recognition of a drug clinical efficiency is the primary and the most important stage. The second equally important stage is certification of a drug as a medication. Manufacturing application represents the third stage which is the closest to a customer. Reasonable price is a phase immediately adjacent to a consumer. Each step has its specific pitfalls.

As for cerebroprotective agents developed by Professor Khavinson, Cortexin has been available for 40 years. All the clinicians consider it as a very potent tool to treat cerebral diseases (especially, age-related degenerative abnormalities including Alzheimer’s disease) in CIS countries. Pinealon (i.e., its own ”little brother”) is being studied by biologists in details using cultural methods (i.e., experimental laboratory trials) and molecular mathematical simulation (as known, mathematics is an exact science). Due to their amazing results, the drug is tipped for promising future as an efficient safe tool to treat age-related neurodegenerative cerebral diseases. This is neither more nor less than panacea.

Due to total safety and absence of ”medication” status, Pinealon is considered as a BAA which is distributed successfully by chain retailers. Epithalon (i.e., an epiphyseal peptide) is a neuroimmunoendocrine ”general officer” and a ”gold standard” of longevity. Having a general property, it can restore structure and function of all the organs and tissues. Representing an epiphyseal extract, it is presented as an injectable dosage form certified as a medication. Although it is not commercially available in pharmacies, the protracted treatment can be received in Drevo Zhizni Clinic of Predictive Medicine in Saint Petersburg. Also, the epiphyseal peptide is available as oral capsules. Despite this tissue extract (Endoluten) is registered as a BAA, it is commercially available in chain retailers. AEDG (i.e., biosynthesized epiphyseal peptide) is available as an injectable product. The experimental therapy can be carried out in Drevo Zhizni Clinic.

As for a peptide produced from 18 amino acid residues which is intended for accompanying drug therapy, unfortunately, it has just already passed nothing but the experimental stage. Even pre-clinical studies have not been conducted yet. Nevertheless, trials demonstrated amazing results. So, due to unique properties and high demand, the product will be studied comprehensively. This is a surprising invention.

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